It is said that smiling is the most beautiful language of humanity, and children who love to laugh are even more likable. But there is a kind of laughter, without the premise of joy, meaningless laughter may indicate a disease that is common in children. When it is found that children are always suddenly paroxysmal laughing and suddenly stop, or there are Secondary sex characteristic in very young children, it is necessary to be alert to the next disease, which is called hypothalamic hamartoma. How to diagnose hypothalamic hamartoma? In addition to making judgments based on the patient's symptoms, physical signs, and medical history, a diagnosis can also be made through examinations such as magnetic resonance imaging. If necessary, magnetoencephalogram or Electroencephalography should also be performed. Magnetic resonance imaging is the most important imaging examination for diagnosing this disease. Is there any harm in getting this disease? Is it feasible without treatment? Here we need to inform you that without intervention, frequent episodes of this disease can affect children's cognitive development, leading to a decline in memory. The disease can also lead to emotional instability and irritability. At the same time, premature development can also have negative effects on children's physical and mental health. What is hypothalamic hamartoma (HH, hereinafter referred to as HH)? It is not a true tumor, HH is a tumor like lesion caused by congenital dysplasia, mostly located in the hypothalamus. The hypothalamus is located in the deep part of the human brain, responsible for human hormone secretion, Thermoregulation, blood glucose regulation, memory, and is caused by dislocation when the hypothalamic plate is formed on the 35-40 days of pregnancy. It is a midline neural tube insufficiency syndrome. With the development of imaging, medical understanding of diseases has improved, and the morphology, magnetic resonance imaging, and clinical manifestations of HH are closely related. What are the clinical manifestations of HH? The typical clinical manifestation of hypothalamic hamartoma is unique and often occurs in early childhood. Typical clinical manifestations include precocious puberty, giggling like epilepsy, cognitive impairment, and psychobehavioral abnormalities, which may include major seizures or other types of epilepsy. Some patients may also have congenital malformations. 1. Premature puberty: Generally, girls aged 10-10.5 and boys aged 12 enter the puberty stage. Clinically, girls enter puberty earlier than 8 years old and boys enter puberty earlier than 9.5 years old, indicating precocious puberty. Girls exhibit symptoms such as menarche or breast development, while boys exhibit symptoms such as penile development, Adam's apple formation, acne, and beards. Children with precocious puberty enter puberty prematurely due to increased levels of estrogen or androgen secretion, resulting in rapid bone development, manifested as excessive growth and early cessation of development. 2. Laughter induced epilepsy: This is the most typical manifestation of hypothalamic hamartoma, characterized by paroxysmal giggling that lasts for several seconds or tens of seconds and suddenly stops. It often occurs in infancy and childhood, and attacks gradually become frequent as age increases. Generally, anti epileptic drugs have poor therapeutic effects. This kind of giggling like seizure is a type of epilepsy. Some patients may develop epilepsy or other types of epilepsy. 3. Cognitive impairment: the child shows inattention, low intelligence, language development delay, hyperactivity disorder, etc., which is related to long-term Seizure. 4. Mental and behavioral abnormalities: The abnormal rate of behavioral problems in children with epilepsy is 25% -30%, significantly higher than that of normal children and children with other chronic diseases. Internalization behavior issues include