In this round of COVID-19, Guangzhou has reported more than 170000 cases of local infection, 90% of whom are asymptomatic, and no deaths. On December 5, the joint prevention and control mechanism of the State Council invited many first-line medical experts to interpret the characteristics of the treatment of patients with this round of epidemic. Experts said that compared with the original strain and the "concerned variant" before, the Omicron variant has significantly enhanced its transmissibility but weakened its virulence. "During the epidemic of the original strain and delta strain, more than half of the infected people had pneumonia, and even more than 60% of the patients had lung manifestations of varying degrees. In this wave of epidemic, more than 90% of the patients showed asymptomatic infection and mild, rarely developed into pneumonia, and even less developed into severe pneumonia." Tang Xiaoping, secretary of the Party Committee of Guangzhou Medical University and director of Guangzhou Institute of Infectious Diseases, said. According to the cases received by COVID-19 designated hospital, the Eighth Affiliated City Hospital of Guangzhou Medical University, since October 22, the hospital has received more than 5000 cases, including more than 500 cases of elderly people over 60 years old. Among them, two cases were diagnosed as severe. Li Yimin, Secretary of the Party Committee of the First Affiliated Hospital of Guangzhou Medical University and Chief Physician of the Department of Critical Care Medicine of Guangzhou Institute of Respiratory Health, said that in this wave of epidemic, the proportion of patients who are really serious is not large, and the more severe patients are manifested by the aggravation of the original underlying diseases, and generally they can gradually recover after active treatment. "I hope we can face it correctly and don't worry too much." Zhang Zhongde, vice president of Guangzhou University of Traditional Chinese Medicine and president of Guangdong Provincial Hospital of Traditional Chinese Medicine, said that after a detailed study of thousands of large samples by an expert group in Guangdong Province, it was determined that the core pathogenesis of the epidemic in Guangzhou was quite different from the original strain that had just started to spread in Wuhan, and the delta strain that had spread more severely in Guangzhou last year. He said that the vast majority of patients showed symptoms of upper respiratory tract infection, mainly local symptoms, including fever, sore throat, dry cough, headache and joint pain in some patients, and gastrointestinal symptoms in some patients, no appetite or diarrhea. After symptomatic treatment, most can relieve symptoms within 24 to 36 hours. "Asymptomatic infections, mild or ordinary patients also turn negative very quickly after rehabilitation, generally 5-7 days, some patients 11 days, most of them can turn negative in about 5 days." Zhang Zhongde said. (Liu Xinshe)