In daily life, in order to save time, many people are used to swallowing medicine directly into their stomach or taking it directly with a small amount of water. In fact, this will not only affect the drug effect, but also easily cause damage to the body, and even lead to pathological changes. So what will be the change of drug effect and harm to the human body if you take medicine without or without water? Relevant experts pointed out that the harm is very great: 1. affect the excretion and absorption of drugs. The onset speed and strength of the drug depend on the dosage of the main drug and the absorption rate of the main drug in the gastrointestinal tract. Before the main drug is absorbed into the blood, it disintegrates into thousands of small particles in the gastrointestinal tract and can be absorbed only after being dissolved. When taking medicine, the drug cannot enter the small intestine from the stomach due to insufficient drinking water, thus affecting the absorption of the drug by the small intestine, resulting in an increase in the residue of the drug in the kidney and causing damage to the kidney (for example, allopurinol, probenecid, compound sulfamethoxazole, levofloxacin and other drugs are easy to form crystals in the kidney after taking, so it is necessary to drink a lot of water to increase their excretion rate). 2. easy to damage esophageal and gastric mucosa. When patients swallow drugs dry or drink insufficient water, the drugs will stay in the esophagus for a long time. If the drugs are acidic or alkaline (such as aspirin, sodium bicarbonate tablets, aminophylline, ferrous sulfate, etc.), they are easy to damage the esophagus and cause lesions. If they are serious, they may become cancerous. Similarly, insufficient drinking water after taking the medicine will affect the decomposition speed of the medicine in the stomach, causing damage to the gastric mucosa and gastritis. 3. cause nausea, vomiting and even suffocation. In order to mask the unpleasant smell in the particles, the capsule usually uses a soft capsule shell to wrap the drug particles. If the patient directly swallows the drug dry when taking medicine or the amount of drinking water is insufficient, it is easy to cause the drug to get stuck in the throat, causing dyspnea or even suffocation when the case is serious. If the case of the capsule is dissolved by saliva, it will also cause the release of unpleasant particles wrapped in the case of the capsule, causing nausea, vomiting and other discomfort. Experts introduce the following correct medication methods: Avoid serving drinks When taking medicine, you should use boiled water with moderate temperature. For example, drinking grapefruit juice while taking hypolipidemic drugs (simvastatin, lovastatin, etc.) is easy to cause serious adverse reactions such as muscle soreness, myositis and smooth muscle dissolution. Avoid lying down immediately Keep sitting or standing position after taking medicine. Avoid taking medicine before going to bed or lying down immediately after taking medicine. If you take alendronate, you should keep sitting or standing for half an hour. If you stay in bed after taking alendronate, it is easy to cause ulcerative esophagitis. Avoid immediate movement Immediate exercise should be avoided after taking medicine to prevent adverse reactions caused by drugs. For example, the antihypertensive drug propranolol will reduce the human heart rate, blood pressure and cardiac output after taking it, which will increase the human fatigue, slow down the movement and make it difficult to breathe, thus increasing the risk of exercise. After taking aspirin, exercise will increase the drug retention time and damage the gastric mucosa. (outlook new era)